Join MSD on an exciting journey to support our mass spectrometry (MS) capabilities within the Target & Pathway Biology group (Singapore). We are seeking a highly motivated and detail-oriented Scientist to join our research team. The successful candidate will provide technical support and expertise in LC-MS and/or MALDI-MS Imaging-based OMICs technologies to support various pipeline projects in basic, translational, and clinical sciences across a diverse range of mass spectrometry (MS)-related applications in proteomics, lipidomics, and small molecule quantitation.

What will you do:
• With supervision be able to support, learn and operate mass spectrometry related activities including assay development, optimization, and mass spectrometer maintenance.
• Assist scientists with in vitro / in vivo / clinical tissue sample preparation for spatial data acquisition by MALDI-MS Imaging workflows and LC-MS based proteomics or metabolomics applications.
• With guidance from senior scientists, employ statistical, bioinformatics and data visualization tools to analyze and interpret LC-MS and MALDI-MS Imaging omics datasets.
• Contribute to and implement the Target and Pathway Biology group and the overall Quantitative Biosciences research strategy aligned with MRL’s drug discovery approaches and organizational objectives.
• Retain an up-to-date knowledge of the key therapeutic area biology, analytical techniques and equipment and carry out literature searches and provide reviews as required in support of priority projects with good communication skills.
• Work collaboratively on MSD research projects with matrix teams within the department and other cross functional teams at MRL to enable the scientific advancement of projects under scientific and administrative direction.
• Assist the group in inventory management, documentations for health and safety, biological materials, risk assessments, management of change documentation, international shipping and capital equipment purchases and maintenance.
• Ensure reliable documentation of experiments and results in electronic notebooks and other documents in compliance with company policies and project needs. Identify the need for and ensure the implementation of risk assessments and SOPs as appropriate.
• Proactively plan and execute own career development strategy with help of manager to advance technical and functional knowledge to design experiments/projects that contribute to overall direction of department/discipline.
• Demonstrate consistent leadership behaviors. Ensure all activities comply with appropriate health and safety legislation, company codes of practice and local rules. Promote a culture of safety and compliance among reports and colleagues.

RESPONSIBILITIES

• Design and application of appropriate analytical strategies (focusing on small molecules) to support development of high value healthy good ingredients with novel functionalities.

• Perform targeted and untargeted metabolomics experiments, LC-MS method development, method validation and troubleshooting, analysis, and interpretation of HRMS and NMR data for biomarker identification and validation.

• Improved productivity and streamlining of existing analysis methods (macro- and micro-nutrients) via automation or new methodologies.

• Supervision of postgraduate/undergraduate students and determine validity of data.

• Creative interpretation and presentation of data to provide insightful correlation.

• Writing reports, publications, conference papers, preparation of research proposals and budget planning. Participation in preparations of funding proposals will be expected.

• Interact and collaborate with a broad range of scientific disciplines with the existing research groups at SIFBI and A*STAR Research Institutes, particularly those focusing on integration of metabolomics, genomic, nutrition and bioinformatics.

• Contribute to the continuous improvement and future development of analytical capability.

Do you have hands-on experience with LC-MS instrumentation for proteomics and excellent people and communication skills? Then you might be the one we are looking for as our new Product Specialist based out of Singapore. We are experiencing increasing demand in the Asia-Pacific region, and we need you to assist our customers and service partners with service and application support as well as provide internal sales support.

Key Tasks and Responsibilities
• Support Evosep One users as a domain expert in LC-MS and proteomics.
• Plan and provide user training.
• Plan and provide installation, preventive maintenance and repair.
• Provide technical support from home-based office.
• Create support related documentation.
• Support our sales team with product expertise and scientific presentations.

This is an exciting career opportunity for a scientist who is passionate about chromatography and mass spectrometry! We are looking for a regional Application Scientist to join our professional team of Application Scientists based in Singapore. The focus of this role is to provide scientific expertise through application presentations, product demonstrations, application training and troubleshooting of our portfolio of LCMS instrumentation and associated workflows including informatics platforms. As part of the Southeast Asia and Taiwan team, you’ll partner with sales, marketing, business development and service team in bringing our mission to life every single day to enable our customers to make the world healthier, cleaner, and safer!

The protein Analytics group at BTI is working to innovate process analytical technology (PAT) in various modality biotherapeutics quality and the biomanufacturing process characterization. The open position is required to utilize liquid-chromatography-mass spectrometry (LCMS)-based techniques for robust and streamlined protein quality attributes characterization and comprehensive proteome profiling and PTMs identification/quantification. As self-motivated and innovative personnel, you will be expected to work independently and closely with industry collaborators and multiple disciplinary team members to address critical challenges in robust at-line and real-time analysis of proteins and provide innovative solutions.

Join Our Research Laboratory in Singapore for an exciting journey to set up the Imaging Mass spectrometry (MS) capabilities within the Target & Pathway Biology group. As  a Senior Scientist, you will focus on developing imaging MS and LC-MS based workflows to support drug discovery pipelines by facilitating decision making based on distribution of proteins, lipids, metabolites, and candidate drugs. Utilizing state of the art  Mass spectrometry platforms within the site, you will be responsible for the application and development of the mass spectrometry technology to understand novel biological regulatory mechanisms, identify disease and pharmacodynamic biomarkers. You will work  closely with other scientists and will coordinate and integrate collaborative projects with the company scientists as well as with academic and clinical investigators in Singapore. You should have excellent background and track record in Mass spectrometry  and diverse interests in systems biology.

What will you do:

• Subject matter expert in mass spectrometry-based platforms and able to provide scientific and technical expertise in the development and application of imaging-MS workflows to support drug discovery pipelines.

• Implement generation, integration, and interpretation of spatial multi-omics and LC-MS datasets (Metabolomics, Lipidomic and Proteomics) as part of a multi-modal approach to drive pipeline decisions. Perform analytical validation and develop QC practices.

• Operate, troubleshoot, and maintain high resolution and triple quadrupole mass spectrometry instrumentation.

• Analyse and interpret data with relevant vendor software and bioinformatics tools and integrate spatial multi-omics IMS datasets as part of a multi-modal approach to measure spatial biology, contextualize drug distribution and identify novel disease biomarkers.

• Continuously optimize and improve the Imaging mass spectrometry platform to support scientific or business processes, seeks opportunities and provides recommendations to enhance capability and support to improve safety, quality, speed, efficiency, and costs.

• Work collaboratively on company’s research projects with matrix teams within the department and other cross functional teams. Proactively pre-empt and respond to emerging project needs to align with business and departmental strategy.

• Identify, evaluate, and recommend innovative analytical technologies and emerging Imaging-MS platforms or capital investment opportunities to maximize the group efficiency and meet scientific objectives.

• Cross-train other scientists in Imaging-MS and LC-MS based proteomics or metabolomics techniques to ensure technical redundancy for these critical workflows in the department

• Operate with high level of autonomy in planning and executing experimentation, creation of research project proposals, reports, publications and other scientific communications related to research activities.

• Ensure reliable documentation of experiments and results in electronic notebooks and other documents in compliance with company policies and project needs.

• Sustain visibility, both inside and outside of disease or functional area by researching and presenting complex ideas and data.

• Proactively plan and execute own career development strategy that advances technical and functional knowledge to design experiments/projects that contribute to overall direction of department/discipline.

• Demonstrate consistent leadership behaviours. Ensure all activities comply with appropriate health and safety legislation, company codes of practice and local rules. Promote a culture of safety and compliance among reports and colleagues. Involve in various  site related activities.